منابع مشابه
Human Th17 cells
The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders. This population of CD4+ Th cells, which has been termed 'Th17', indeed plays an apparently critical role in the pathogenesis of some murine ...
متن کاملTh17 Cells in Cancer
T helper (Th)17 cells regulate host defense and exacerbate autoimmune diseases, yet their role in tumor immunity remains controversial with reports that Th17 cells could either promote or suppress tumor growth, depending on the type of malignancy or means of therapeutic intervention. This review discusses how inflammatory signals (such as cytokines and co-stimulatory/co-inhibitory molecules) in...
متن کاملTh17 cells in human disease.
SUMMARY Our understanding of the role of T cells in human disease is undergoing revision as a result of the discovery of T-helper 17 (Th17) cells, a unique CD4(+) T-cell subset characterized by production of interleukin-17 (IL-17). IL-17 is a highly inflammatory cytokine with robust effects on stromal cells in many tissues. Recent data in humans and mice suggest that Th17 cells play an importan...
متن کاملA role for Th17 cells in autoimmune diabetes Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice Running Title: A role for Th17 cells in autoimmune diabetes
This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in pr...
متن کاملTh17 Cells in Immunity and Autoimmunity
Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although ...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2018
ISSN: 1600-6135
DOI: 10.1111/ajt.15158